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(11.14)【院长论坛】DNA Mismatch Repair in Cancer and Therapy

发布日期:2019-11-18    浏览次数:



报告题目:DNA Mismatch Repair in Cancer and Therapy

:Guo-Min Li, PhD

             Professor, The Reece A. Overcash, Jr. Distinguished Chair,

             Director, The Reece A. Overcash, Jr. Center for Research on Colon Cancer

             Department of Radiation Oncology

             University of Texas Southwestern Medical Center

时    间:2019 年11 月14 日(星期四)上午10:00-11:00





Dr. Guo-Min Li is a professor and the Reece A. Overcash Jr. Distinguished Chair for Research on Colon Cancer at the UT Southwestern. He received his BS and MS degrees from Wuhan University and his Ph.D. degree from the Department of Chemistry, Wayne State University. He performed his postdoctoral training with Nobel laureate Dr. Paul Modrich (Chemistry, 2015) at Duke University. Before joining UT Southwestern, Dr. Li held professorship the University of Kentucky and the University of Southern California.

Dr. Li studies the mechanism of DNA mismatch repair (MMR) and its roles in cancer susceptibility and therapy. He discovered MMR defects as the genetic basis of hereditary non-polyposis colorectal cancer (HNPCC) and sporadic colorectal cancers displaying microsatellite instability (MSI). His laboratory identified and characterized the majority of components required for human MMR, and reconstituted the human MMR reaction in vitro. He is also responsible for discovering histone mark H3K36me3 as an essential factor for MMR in vivo via recruiting MMR proteins to replicating chromatin. His recent work has elucidated the molecular basis by which MMR-deficient cancers are responsiveness to anti-PD-1 immunotherapy. In this lecture, Dr. Li will give a brief history of MMR and its role in maintaining genome stability, followed by his work in cancer immunotherapy.

Representative Publications:

1. Fang J, Huang Y, Mao G, Yang S, Rennert G, Gu L, Li H, Li GM. (2018) Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3-MutSα interaction. Proc Natl Acad Sci U S A. 115:9598-9603.

2. Guo J, Gu L, Leffak M, Li GM. (2017) MutSβ promotes trinucleotide repeat expansion by recruiting DNA polymerase β to nascent (CAG)n or (CTG)n hairpins for error-prone DNA synthesis. Cell Res. 26:775-86.

3. Ortega J, Li JY, Lee S, Tong D, Gu L, Li GM. (2015) Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis. Proc Natl Acad Sci U S A. 112:5667-72.

4. Li F, Mao G, Tong D, Huang J, Gu L, Yang W, Li GM. (2013) The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell. 153:590-600.

5. Zhang Y, Yuan F, Presnell SR, Tian K, Gao Y, Tomkinson AE, Gu L, Li GM. (2005) Reconstitution of 5'-directed human mismatch repair in a purified system. Cell. 122:693-705.